An exercise-inducible metabolite that suppresses feeding and obesity

  • Eriksson KF & Lindgarde F. Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise. diabetology 34891-898 (1991).

    CAS ArticleGoogle Scholar

  • Rejeski, WJ et al. Lifestyle change and mobility in obese adults with type 2 diabetes. N. Engl. J. Med. 3661209-1217 (2012).

    CAS ArticleGoogle Scholar

  • Stampfer, MJ, Hu, FB, Manson, JE, Rimm, EB & Willett, WC Primary prevention of coronary heart disease in women through diet and lifestyle. N. Engl. J. Med. 34316-22 (2000).

    CAS ArticleGoogle Scholar

  • Helmrich SP, Ragland DR, Leung RW & Paffenbarger RS ​​Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 325147-152 (1991).

    CAS ArticleGoogle Scholar

  • Rawshani, A. et al. Risk factors, mortality, and cardiovascular outcomes in patients with type 2 diabetes. N. Engl. J. Med. 379633–644 (2018).

    ArticleGoogle Scholar

  • Sanford, JA et al. Molecular Transducers of Physical Activity Consortium (MoTrPAC): mapping the dynamic responses to exercise. Cell 1811464–1474 (2020).

    CAS ArticleGoogle Scholar

  • Contrepois, K. et al. Molecular choreography of acute exercise. Cell 1811112–1130.e16 (2020).

    CAS ArticleGoogle Scholar

  • Morville T, Sahl RE, Moritz T, Helge JW & Clemmensen C. Plasma metabolome profiling of resistance exercise and endurance exercise in humans. Cell Rep. 33108554 (2020).

    CAS ArticleGoogle Scholar

  • Lewis, GD et al. Metabolic signatures of exercise in human plasma. science translation medication 233ra37 (2010).

    ArticleGoogle Scholar

  • Roberts, LD et al. β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 1996-108 (2014).

    CAS ArticleGoogle Scholar

  • Stanford, KI et al. 12,13-diHOME: an exercise-induced lipokine that increases skeletal muscle fatty acid uptake. Cell Metab. 271111–1120.e3 (2018).

    CAS ArticleGoogle Scholar

  • Reddy, A. et al. pH-gated succinate secretion regulates muscle remodeling in response to exercise. Cell 18362–75.e17 (2020).

    CAS ArticleGoogle Scholar

  • Yuan, Y. et al. Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation. EMBO J 39e103304 (2020).

    CAS ArticleGoogle Scholar

  • Klein, AB et al. Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise. nat. community 121041 (2021).

    ADSCAS ArticleGoogle Scholar

  • Green, HJ & Fraser, IG Differential effects of exercise intensity on serum uric acid concentration. Med.Sci. sports exercise 2055-59 (1988).

    CAS ArticleGoogle Scholar

  • Schranner, D., Kastenmüller, G., Schönfelder, M., Römisch-Margl, W. & Wackerhage, H. Metabolite concentration changes in humans after a bout of exercise: a systematic review of exercise metabolomics studies. Sports. Medical Open 611 (2020).

    ArticleGoogle Scholar

  • Gaffney, B. & Cunningham, EP Estimation of genetic trend in racing performance of thoroughbred horses. Nature 332722-724 (1988).

    ADSCAS ArticleGoogle Scholar

  • Hagenfeldt, L. & Naglo, AS New conjugated urinary metabolites in intermediate type maple syrup urine disease. clinical chim. Acta 16977-83 (1987).

    CAS ArticleGoogle Scholar

  • Bottesini C, Tedeschi T, Dossena A & Sforza S. Enzymatic production and degradation of cheese-derived non-proteolytic aminoacyl derivatives. Amino Acids 46441–447 (2014).

    CAS ArticleGoogle Scholar

  • Sgarbi, E. et al. Microbial origin of non-proteolytic aminoacyl derivatives in long ripened cheeses. Food Microbiol. 35116-120 (2013).

    CAS ArticleGoogle Scholar

  • Jansen, RS et al. N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids. proc. Natl Acad. science United States 1126601-6606 (2015).

    ADSCAS ArticleGoogle Scholar

  • Sharma, R. et al. Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity. J.Clin. invest 131e136055 (2021).

    CAS ArticleGoogle Scholar

  • The Tabula Muris Consortium. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature 562367–372 (2018).

    ADSCAS ArticleGoogle Scholar

  • Locke, AE et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 518197-206 (2015).

    CAS ArticleGoogle Scholar

  • Ringholm, S. et al. PGC-1α is required for exercise and exercise training-induced UCP1 up-regulation in mouse white adipose tissue. PLoS ONE 8the64123 (2013).

    ADDS ArticleGoogle Scholar

  • Kim, YJ, Kim, HJ, Lee, WJ & Seong, JK A comparison of the metabolic effects of treadmill and wheel running exercise in mouse model. Lab. anime reserve 361–8 (2020).

    ArticleGoogle Scholar

  • DeWolf, CJF et al. cGMP transport by vesicles from human and mouse erythrocytes. FEBS J 274439-450 (2007).

    ArticleGoogle Scholar

  • Smith, CA et al. XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal. chem. 78779-787 (2006).

    CAS ArticleGoogle Scholar

  • Agudelo, LZ et al. Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell 15933-45 (2014).

    CAS ArticleGoogle Scholar

  • Coxon, JP et al. GABA concentration in sensorimotor cortex following high-intensity exercise and relationship to lactate levels. J Physiol. 596691–702 (2018).

    CAS ArticleGoogle Scholar

  • Human Energy Requirements: Report of a Joint FAO/WHO/UNU Expert Consultation (FAO, WHO, UNU, 2005).

  • Sanjana NE, Shalem O & Zhang F. Improved vectors and genome-wide libraries for CRISPR screening. nat. methods 11783–784 (2014).

  • Leave a Comment